PurposeTo use the power of knowledge acquisition and machine learning in the development of a collaborative computer classification system based on the features of age-related macular degeneration (AMD).MethodsA vocabulary was acquired from four AMD experts who examined 100 ophthalmoscopic images. The vocabulary was analyzed, hierarchically structured, and incorporated into a collaborative computer classification system called IDOCS. Using this system, three of the experts examined images from a second set of digital images compiled from more than 1000 patients with AMD. Images (...) were annotated, and features were identified and defined. Decision trees, a machine learning method, were trained on the data collected and used to extract patterns. Interrelationships between the data from the different clinicians were investigated.ResultsSix drusen classes in the structured vocabulary were largely sufficient to describe all the identified features. The decision trees classified the data with 76.86% to 88.5% accuracy and distilled patterns in the form of hierarchical trees composed of 5 to 15 nodes. Experts were largely consistent in their characterization of soft, and to a lesser extent, hard drusen, but diverge in definition of other drusen. Size and crystalline morphology were the main determinants of drusen type across all experts.ConclusionsMachine learning is a powerful tool for the characterization of disease phenotypes. The creation of a defined feature set for AMD will facilitate the development of an IDOCS-based classification system. (shrink)

This text presents a comparative study of two of the most influential Indian masters, Śāntideva and Śaṅkara. Exploring the philosophical concerns of the nature of the self, Todd demonstrates that an ethics of altruism is still possible within a metaphysics which assumes there to be no independent self.

A broad evolutionary perspective is essential to fully reverse figure and ground in the rationality debate. Humans' evolved psychological architecture was designed to produce inferences that were adaptive, not normatively logical. This perspective points to several predictable sources of errors in modern laboratory reasoning tasks, including inherent, systematic biases in information-processing systems explained by Error Management Theory.

Here, we describe how Casas Grandes Medio period (AD 1200 to 1450) shamanic practices of the North American Southwest used tobacco shamanism, a ritual stance called the Tennessee Diviner (TD) posture, and cultural expectations to generate trance experiences of soul flight and divination. We introduce a conceptual model that holds that specific trance experiences are the emergent result of human minds interacting with additional factors including entheogens, cultural expectations, physiological states, postures/movement, and sound/stimulation. Experimental and ethnographic evidence indicates initiating trance (...) with either tobacco intoxication or the TD posture accompanied with a rapidly beating drum or rattle corresponds with perceptions of soul flight, transformation, and divination/information acquisition. Both have similar results but pairing them together as they were during the Medio period likely helped ensure the culturally desired trance experiences. This practice of mutually reinforcing factors was likely part of tobacco‐based shamanism found in other New World cultures as well. We suggest our general model can be applied to other contexts to examine how various aspects of trance induction interact to produce the cultural patterns (and resulting cosmological and spiritual frameworks) anthropologists have documented in other cultures. (shrink)

Canonical, system-building philosophers often have a characteristic “way of looking at things,” that is, a specific method for doing philosophy that they apply to a wide array of topics, and which they view as rooted in some basic propositions about, for example, rationality, human nature, or the nature of reality. This is part of what makes them compelling. For contemporary interpreters, however, it raises questions about how much these foundational claims need to impact our ability to understand or learn from (...) other aspects of their thought—especially if we are leery of the foundational claims. Such interpretive vexations are especially urgent with Hegel: Hegel certainly has a characteristic way of looking at.. (shrink)

This paper argues that conceptualizing unity as "interconnection" (rather than reduction) provides a more fruitful and versatile framework for the philosophical study of scientific unification. Building on the work of Darden and Maull, Kitcher, and Kincaid, I treat unity as a relationship between fields: two fields become more integrated as the number and/or significance of interfield connections grow. Even when reduction fails, two theories or fields can be unified (integrated) in significant ways. I highlight two largely independent dimensions of unification. (...) Fields are theoretically unified to the extent that we understand how the ontologies, concepts, and generalizations of these fields are connected. (Reductionism is one form of theoretical unity, but not the only form). Fields are practically unified through heuristic connections (e.g., using the heuristics of one field to generate hypotheses in another field) and by the development of methods for integrating the qualitatively distinct bodies of data generated by the two fields. I discuss the relationship between paleontological and neontological systematics to illustrate the utility of conceptualizing unity as interconnection. (shrink)

SummaryJohn Dalton's atomic theory, with its postulate of compound formation through atom-to-atom combination, brought a new perspective to weight relationships in chemical reactions. A presumed one-to-one combination of atoms A and B to form a simple compound AB allowed Dalton to construct his first table of relative atomic weights from literature analyses of appropriate binary compounds. For such simple binary compounds, the atomic theory had little advantages over affinity theory as an explanation of fixed proportions by weight. For ternary compounds (...) of the form AB2, however, atomic theory made quantitative predictions that were not deducible from affinity theory. Atomic theory required that the weight of B in the compound AB2 be exactly twice that in the compound AB. Dalton, Thomas Thomson and William Hyde Wollaston all published within a few years of each other experimental data that claimed to give the predicted results with the required accuracy. There are nonetheless several experimental barriers to obtaining the desired integral multiple proportions. In this paper I will discuss replication experiments which demonstrate that only Wollaston's results are experimentally reliable. It is likely that such replicability explains why Wollaston's experiments were so influential. (shrink)

This paper is a defense of "explanatory pluralism" (i.e., the view that some events can be correctly explained in two distinct ways). To defend pluralism, I identify two distinct (but compatible) styles of explanation in paleobiology. The first approach ("actual sequence explanation") traces out the particular forces that affect each species. The second approach treats the trend as "passive" or "random" diffusion away from a boundary in morphological space. I argue that while these strategies are distinct, some trends are correctly (...) explained in both ways. Further, since neither strategy can be reduced or eliminated from paleobiology, we should accept that both strategies can provide correct explanations for a single trend. (shrink)

The study explored the motivations behind Australian wool producers’ intentions regarding mulesing; a surgical procedure that will be voluntarily phased out after 2010, following retailer boycotts led by People for the Ethical Treatment of Animals. Telephone interviews were conducted with 22 West Australian wool producers and consultants to elicit their behavioral, normative and control beliefs about mulesing and alternative methods of breech strike prevention. Results indicate that approximately half the interviewees intend to continue mulesing, despite attitudes toward the act of (...) mulesing being quite negative. This indicates that attitudes alone are unlikely to be good predictors of this goal directed behavior. Most respondents believed mulesing was more effective and involved less cost, time, and effort than the currently available alternatives to prevent breech strike. Further, they felt relatively little social pressure, as they believed few consumers were concerned about mulesing. However, they noted that if consumer sentiment changed they would likely change their practices. Thus, attitudes are likely to be only one of several factors influencing intentions to change farm practices to address societal concerns about animal welfare. Further, mulesing appears to be goal - directed behavior , suggesting that other factors depicted by the Model of Goal-directed Behavior (MGB; Perugini and Bagozzi In: Br J Soc Psychol, 40: 79–98, 2001 ) may be worth exploring in this context. Finally, these results provide insight into how policy makers may influence farmers to change practices in response to societal pressure for improving farm animal welfare. (shrink)

The environmentally responsive molecular chaperone Hsp90 assists the maturation of many key regulatory proteins. An unexpected consequence of this essential biochemical function is that genetic variation can accumulate in genomes and can remain phenotypically silent until Hsp90 function is challenged. Notably, this variation can be revealed by modest environmental change, establishing an environmentally responsive exposure mechanism. The existence of diverse cryptic polymorphisms with a plausible exposure mechanism in evolutionarily distant lineages has implications for the pace and nature of evolutionary change. (...) Chaperone‐mediated storage and release of genetic variation is undoubtedly rooted in protein‐folding phenomena. As we discuss, proper protein folding crucially affects the trajectory from genotype to phenotype. Indeed, the impact of protein quality‐control mechanisms and other fundamental cellular processes on evolution has heretofore been overlooked. A true understanding of evolutionary processes will require an integration of current evolutionary paradigms with the many new insights accruing in protein science. BioEssays 26:348–362, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

One of the principal difficulties in assessing Science as aProcess (Hull 1988) is determining the relationship between the various elements of Hull's theory. In particular, it is hard to understand precisely how conceptual selection is related to Hull's account of the social dynamics of science. This essay aims to clarify the relation between these aspects of his theory by examining his discussion of the``demic structure'' of science. I conclude that the social account cando significant explanatory work independently of the selectionistaccount. (...) Further, I maintain that Hull's treatment of the demicstructure of science points us toward an important set of issues insocial epistemology. If my reading of Science as a Process iscorrect, then most of Hull's critics (e.g., those who focus solelyon his account of conceptual selection) have ignored promisingaspects of his theory. (shrink)

Gould's Structure ofEvolutionary Theory argues that Darwinism hasundergone significant revision. Although Gouldsucceeds in showing that hierarchicalapproaches have expanded Darwinism, hiscritique of adaptationism is less successful. Gould claims that the ubiquity of developmentalconstraints and spandrels has forced biologiststo soften their commitment to adaptationism. Iargue that Gould overstates his conclusion; hisprincipal claims are compatible with at leastsome versions of adaptationism. Despite thisweakness, Gould's discussion of adaptationism –particularly his discussions of the exaptivepool and cross-level spandrels – shouldprovoke new work in evolutionary theory and (...) thephilosophy of biology. (shrink)

In Roman Catholic moral theology there is an ongoing debate between the proportionalist or revisionist school and the traditionalist school that has developed what is referred to as the ‘New Natural Law Theory’ or ‘Basic Goods Theory’ . The stakes in this debate have been raised with Pope John Paul II's encyclical Veritatis Splendor on fundamental moral theology that condemned ‘proportionalism’ or ‘teleologism’ as an ethical theory while utilizing many of the ideas, concepts, and terminology of the BGT, thereby implicitly (...) endorsing that ethical theory. While absolute norms and intrinsically evil acts have frequently been the focus of debate between these two schools, what is it that divides them fundamentally, on the level of ethical method? It is the role and function of reason and experience as two sources of moral knowledge, in part, that distinguish these two versions of natural law on the most basic level. While the BGT has a strict hierarchy of the sources of moral knowledge that posits the hierarchical magisterium as the definitive interpreter of reason and experience, revisionists posit a more dialogical relationship between reason, experience, and the magisterium. On certain ethical issues , the experience of the faithful as well as the rational arguments developed by revisionist Catholic moral theologians challenge some of the normative claims of the magisterium. This paper investigates the methodological use of reason and experience in each theory's interpretation of natural law and how and why these two sources of moral knowledge lead to fundamentally divergent normative claims on particular ethical issues. (shrink)

Eight story-reflections, each based on a different Beatitude, offer accounts of immigrant children who fled Central America on their own to escape violence and poverty. Artwork created by immigrant youth and meditations written by Jesuit Father Leo O'Donovan accompany the stories.

The consideration of normative ethics and methodology is a relatively recent phenomena in Catholic moral theology. Similar to any nascent discussion, having adopted terms and concepts from one conceptual genre, Britisch-analytic philosophy, into a radically other genre, Catholic moral theology, one then needs to begin the work of clarifying how, and to what extent, those terms and concepts contribute to the overall project of moral theology as a science. As Pope John Paul II's encyclical Veritatis Splendor attests, this incorporation has (...) met with a great deal of resistance based on misunderstandings of the nature and purpose of normative ethics and methodology. Deontology and Teleology is a pioneer account which exposes and clarifies many of the terminological and conceptual ambiguities inherent to this discussion. It begins with an investigation of C.D. Broad's meta-ethical division of theories into deontology and teleology, and the epistemological/ontological foundations on which he established this division. An analysis of how and why Broad's theory has been incorporated into Catholic discussions on the foundation and formulation of norms along with the inherent difficulties of such an incorporation is then taken up. Finally, this study argues and substantiates through detailed historical analysis that a fundamental difference between traditionalists and revisionists in their relative perspectives on norms rest in the traditional understanding and moral evaluation of the human act, specifically, the objectum, circumstantiae and finis (fontes moralitates). This is an indispensable resource work for those interested in fundamental moral theology and lays the foundation for pursuing further the complex question of normative ethics in Catholic moral theology. (shrink)

We introduce a new approach to analyzing the interaction between classical and quantum systems that is based on a limiting procedure applied to multi-particle Schrödinger equations. The limit equations obtained by this procedure, which we refer to as the classical-quantum limit, govern the interaction between classical and quantum systems, and they possess many desirable properties that are inherited in the limit from the multi-particle quantum system. As an application, we use the classical-quantum limit equations to identify the source of the (...) non-local signalling that is known to occur in the classical-quantum hybrid scheme of Hall and Reginatto. We also derive the first order correction to the classical-quantum limit equation to obtain a fully consistent first order approximation to the Schrödinger equation that should be accurate for modeling the interaction between particles of disparate mass in the regime where the particles with the larger masses are effectively classical. (shrink)

We construct, for any finite dimension n, a new hidden measurement model for quantum mechanics based on representing quantum transition probabilities by the volume of regions in projective Hilbert space. For n=2 our model is equivalent to the Aerts sphere model and serves as a generalization of it for dimensions n .≥ 3 We also show how to construct a hidden variables scheme based on hidden measurements and we discuss how joint distributions arise in our hidden variables scheme and their (...) relationship with the results of Fine [J. Math. Phys. 23 1306 (1982)]. (shrink)

Bennett and Schumacher’s postselected quantum teleportation is a model of closed timelike curves (CTCs) that leads to results physically different from Deutsch’s model. We show that even a single qubit passing through a postselected CTC (P-CTC) is sufficient to do any postselected quantum measurement with certainty, and we discuss an important difference between “Deutschian” CTCs (D-CTCs) and P-CTCs in which the future existence of a P-CTC might affect the present outcome of an experiment. Then, based on a suggestion of Bennett (...) and Smith, we explicitly show how a party assisted by P-CTCs can distinguish a set of linearly independent quantum states, and we prove that it is not possible for such a party to distinguish a set of linearly dependent states. The power of P-CTCs is thus weaker than that of D-CTCs because the Holevo bound still applies to circuits using them, regardless of their ability to conspire in violating the uncertainty principle. We then discuss how different notions of a quantum mixture that are indistinguishable in linear quantum mechanics lead to dramatically differing conclusions in a nonlinear quantum mechanics involving P-CTCs. Finally, we give explicit circuit constructions that can efficiently factor integers, efficiently solve any decision problem in the intersection of NP and coNP, and probabilistically solve any decision problem in NP. These circuits accomplish these tasks with just one qubit traveling back in time, and they exploit the ability of postselected closed timelike curves to create grandfather paradoxes for invalid answers. (shrink)

This article explores the extent to which consumers consider ethics in luxury goods consumption. In particular, it explores whether there is a significant difference between consumers’ propensity to consider ethics in luxury versus commodity purchase and whether consumers are ready to purchase ethical-luxury. Prior research in ethical consumption focuses on low value, commoditized product categories such as food, cosmetics and high street apparel. It is debatable if consumers follow similar ethical consumption patterns in luxury purchases. Findings indicate that consumers’ propensity (...) to consider ethics is significantly lower in luxury purchases when compared to commoditized purchases and explores some of the potential reasons for this reduced propensity to identify or act upon ethical issues in luxury consumption. (shrink)

Two renowned, award-winning authors in the field of virtue and sexual ethics introduce and then apply their ethical method to such topics as relativism, ecology, bioethics, sexual ethics, and liberation theology. The result is a foundational text for undergraduate courses in Catholic theological ethics.

This work is an investigation of the ongoing methodical reconstruction of Catholic moral theology. As such it is based on and honors the work of Norbert Rigali, S.J., one of the most important contributors to this reconstruction.The decisive break from the traditional manual approach to moral theology represented by Vatican II reoriented moral theology away from universal natural law morality based on the commandments to a morality based on specifically Christian sources. This reorientation, however, was not an either/or but a (...) both/and proposition. Father Norbert Rigali, S.J. has been an inspiration and a challenge to moral theologians working toward reconstruction. This essays in this collection address four questions in the renewal movement: an investigation of normative methods, a clarification of sources, an investigation of the tension between natural law morality and Christian ethics and/or morality, and a combination of methodical insights of philosophy and traditional Christian sources in their investigation of biomedical ethical issues. (shrink)

The historic material culture produced by American Cold War nuclear weapons testing includes objects of scientific inquiry that can be generally categorized as being either ephemeral or enduring. Objects deemed to be ephemeral were of a less substantial nature, being impermanent and expendable in a nuclear test, while enduring objects were by nature more durable and long-lasting. Although all of these objects were ultimately subject to disappearance, the processes by which they were transformed, degraded, or destroyed prior to their disappearing (...) differ. Drawing principally upon archaeological theory, this paper proposes a functional dichotomy for categorizing and studying the historical trajectories of nuclear weapons testing technoscience artifacts. In examining the transformation patterns of steel towers and concrete blockhouses in particular, it explores an associated loss of scientific method that accompanies a science object's disappearance. (shrink)

Todd A. Gooch - The New Hegelians: Politics and Philosophy in the Hegelian School - Journal of the History of Philosophy 45:4 Journal of the History of Philosophy 45.4 667-668 Muse Search Journals This Journal Contents Reviewed by Todd Gooch Eastern Kentucky University Douglas Moggach, editor. The New Hegelians: Politics and Philosophy in the Hegelian School. Cambridge-New York: Cambridge University Press, 2006. Pp. xiv + 345. Cloth, $75.00. Of the thirteen essays collected in this volume, several of which (...) discuss more than one thinker, approximately three are devoted to Marx, two to Feuerbach, two to Bruno Bauer, two to Max Stirner, and one each to Eduard Gans, Edgar Bauer, and Friedrich Engels. Underlying the diversity of their individual positions, these "New Hegelians" were united by a common interest in exploiting the conceptual resources of Hegelian.. (shrink)

Llewellyn's proposal that rapid eye movement dreaming reflects elaborative encoding mediated by the hippocampus offers an interesting perspective for understanding hallucinations accompanying sleep paralysis. SP arises from anomalous intrusion of REM processes into waking consciousness, including threat-detection systems mediated by the amygdala. Unique aspects of SP hallucinations offer additional prospects for investigation of Llewellyn's theory of elaborative encoding.

Moreover, he examines the reception of Ottoa (TM)s ideas after World War One. The volume contains name and subject indexes.

Numerous experiments have examined whether moving stimuli capture spatial attention but none have sought to determine whether visual features of looming and receding objects are extracted in a capacity-free manner. The current experiment used the task-choice procedure originated by Besner and Care to examine this possibility. Stimuli were presented in 3D space by manipulating retinal disparity. Results indicate that features of an object are extracted in a capacity-free manner for both looming and receding objects for participants who consciously perceive motion (...) but not for participants who do not consciously perceive motion. These results suggest that the cognitive system is biased to process potentially animate objects, perhaps because of the evolutionary advantage this cognitive ability may provide. (shrink)

There is a strong impetus in international agricultural development to close ‘gender gaps’ in agricultural productivity. The goal of empowering women is often framed as the solution to closing these gaps, stimulating the proliferation of new indicators and instruments for the targeting, measurement, and tracking of programmatic goals in research for agricultural development. Despite these advances, current measurements and indices remain too simplified in terms of unit and scope of analysis, as well as being fundamentally flawed in how they aim (...) to capture the relevance of ‘gender’ in diverse local contexts. We propose that the impulse to apply exogenously defined and weakly validated ‘women’s empowerment’ measures to diverse local contexts risks prioritizing practical expedience over scientific accuracy and societal relevance. Furthermore, the application of such measures risks creating the impression that programmatic “gender targets” are being achieved, while simultaneously undermining substantive gender transformative goals. The authors conclude that a different methodological approach grounded in participatory and qualitative methods is needed to create more meaningful metrics for assessing progress towards women’s empowerment. (shrink)

Proposed models of closed timelike curves have been shown to enable powerful information-processing protocols. We examine the simulation of models of CTCs both by other models of CTCs and by physical systems without access to CTCs. We prove that the recently proposed transition probability CTCs are physically equivalent to postselection CTCs, in the sense that one model can simulate the other with reasonable overhead. As a consequence, their information-processing capabilities are equivalent. We also describe a method for quantum computers to (...) simulate Deutschian CTCs. In cases for which the overhead is reasonable, it might be possible to perform the simulation in a table-top experiment. This approach has the benefit of resolving some ambiguities associated with the equivalent circuit model of Ralph et al. Furthermore, we provide an explicit form for the state of the CTC system such that it is a maximum-entropy state, as prescribed by Deutsch. (shrink)

Previously we reported a three-factor structure for hallucinations accompanying sleep paralysis . These earlier analyses were, however, based on retrospective accounts. In a prospective study, 383 individuals reported individual episodes online providing further evidence for the three-factor structure as well as clearer conceptually meaningful relations among factors than retrospective studies. In addition, reports of individual episodes permitted a more fine-grained analysis of the internal structure of factors to assess predictions based on the hypothesis that a sensed or felt presence is (...) a core experience affecting other SP hallucinations. Results were generally consistent with this hypothesis. In particular, associations among, and temporal stability of, sensory hallucinations were largely explained by their common association with FP. The findings are consistent with REM initiation of a threat activated vigilance system with pervasive effects on the SP experience and suggest a potential model for the thematic organization of nightmares and dreams more generally. (shrink)

Combined oral contraceptives have been demonstrated to have significant benefits for the treatment and prevention of disease. These medications also are associated with untoward health effects, and they may be directly contraceptive. Prescribers and users must compare and weigh the intended beneficial health effects against foreseeable but unintended possible adverse effects in their decisions to prescribe and use. Additionally, those who intend to abide by Catholic teachings must consider prohibitions against contraception. Ethical judgments concerning both health benefits and contraception are (...) approached in this essay through an overview of the therapeutic, prophylactic, untoward, and contraceptive effects of COC and discussion of magisterial and traditional Catholic teachings from natural law. Discerning through the principle of double effect, proportionate reason, and evidence gathered from the sciences, medical and moral conclusions are drawn that we believe to be fully compliant with good medicine and Catholic teaching. (shrink)

In Western Kenya, smallholder dairy production is becoming incrementally commercialized through the commodification and sale of milk through formal market channels. While commercialization is often construed as a way to boost rural livelihoods through increased income from milk, emerging evidence suggests that married women are not directly benefiting from formal milk market participation. This critical issue of gender power imbalance has been framed by development interventions in economic efficiency and social justice perspectives, but thus far interventions in the sector have (...) not addressed how underlying social-market mechanisms embedded in gendered ideology influence smallholder engagement in dairy commercialization. Drawing on feminist theories of power and social embeddedness, this study investigates how gendered power relationships materialize and influence formal milk marketing engagement and practices in Western Kenya. Facilitated discussion groups with smallholder farmers revealed the gendered ideologies and norms that ascribe masculinized meaning to cattle, milk, and commercial enterprise. Key informant interviews with commercial dairy management and farmers were used to identify current practices for increasing women’s formal market participation—namely, direct payments to women for milk deliveries. Findings from this study indicate that cattle and formal dairy market participation are imbued with gendered meaning that create legitimacy around men’s privilege over dairy proceeds. Interventions in the sector aimed at addressing gender power imbalances must acknowledge this dynamic, and accept the social trade-offs and gendered costs of dairy commercialization. (shrink)